Protein Details: Small conductance calcium-activated potassium channel protein 2

Protein ID

ICDB_Pro_1507

Protein Name

Small conductance calcium-activated potassium channel protein 2

Gene Name

KCNN2

Organism

Homo sapiens (Human)

Length

579 amino acids

AlphaFoldDB

AF-Q9H2S1-F1-model_v4.pdb

Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization

Sequence

MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

PDB Structures

5V02 5WBX 5WC5 6ALE

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Neurodevelopmental Disorder With Or Without Variable Movement Or Behavioral Abnormalities and Dystonia;Myoclonic

Location

Expressed in atrial myocytes (at protein level). Widely expressed.

DOI ID

10.1074/jbc.m001562200; 10.1074/jbc.m307508200; 10.1038/ng1285; 10.1038/nature02919; 10.1101/gr.2596504; 10.1074/jbc.272.37.23195; 10.1093/braiwaa346; 10.1111/ene.14228

RefSeq

NP_001265133.1; NP_067627.2; NP_740721.1 [Q9H2S1-2]